Coamorphous Atorvastatin Calcium to Improve its Physicochemical and Pharmacokinetic Properties

coamorphous drug system to improve physicochemical properties of atorvastatin calcium

Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities.

Curcumin (CUR), a natural polyphenol isolated from tumeric ( Curcuma longa ), has been documented to possess antioxidant and anticancer activities. Unfortunately, the compound has poor aqueous solubility, which results in poor bioavailability following high doses by oral administration. To improve the solubility of CUR, we developed a novel curcumin nanoparticle system (CURN) and investigated i...

Simultaneous Determination of Losartan and Atorvastatin in Rat Plasma and Its Application to Pharmacokinetic Study

A simple, rapid, economic and precise RP-HPLC method for simultaneous analysis of Losartan (LOS) and Atorvastatin (ATR) in rat plasma has been developed and validated. Valsartan (VAL) was used as an internal standard. Extraction of the drug from the plasma was carried out by precipitation method. Analysis was performed using Kromasil C18 column (250  4.6 mm; 5μ) with mobile phase consisting of...

petrology and geochemistry of khar-bash (western shahrood) and its relation ship to iron mineralization

منطقه مورد مطالعه در 23 کیلومتری جنوب غرب شهرستاشاهرود قرار دارد که در نقشه 100000/1 شاهرود قرار گرفته است.ناحیه مورد مطالعه در تقسیمات ساختاری ایران بخشی از زون البرز شرقی است . در طی سنوزوئیک این زون به شدت تحت تأثیر فازهای کوهزایی آلپی قرار گرفته و فعالیت های آتشفشانی انوسن در قسمت های غربی آن دیده می شود . از نظر ترکیب سنگ شناسی منطقه مورد مطالعه متنوع و بیشتر شامل سنگ های رسوبی مانند : آ...

construction and validation of translation metacognitive strategy questionnaire and its application to translation quality

like any other learning activity, translation is a problem solving activity which involves executing parallel cognitive processes. the ability to think about these higher processes, plan, organize, monitor and evaluate the most influential executive cognitive processes is what flavell (1975) called “metacognition” which encompasses raising awareness of mental processes as well as using effectiv...